Pseudomonas aeruginosa PAO1, PA1268 (lhpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1268
Name
lhpA
Replicon chromosome
Genomic location 1377439 - 1378383 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249959.1
GI 15596465
Affymetrix PA1268_at
Entrez 881376
GenBank AAG04657.1
INSDC AAG04657.1
NCBI Locus Tag PA1268
protein_id(GenBank) gb|AAG04657.1|AE004556_7|gnl|PseudoCAP|PA1268
TIGR NTL03PA01269
UniParc UPI000003E74A
UniProtKB Acc Q9I476
UniProtKB ID 4HYPE_PSEAE
UniRef100 UniRef100_Q9I476
UniRef50 UniRef50_Q9I476
UniRef90 UniRef90_Q9I476

Product

Feature Type CDS
Coding Frame 1
Product Name
Hydroxyproline 2-epimerase, LhpA
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -7.80
Kyte-Doolittle Hydrophobicity Value -0.137
Molecular Weight (kDa) 33.5
Isoelectric Point (pI) 5.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2AZP STRUCTURAL GENOMICS, UNKNOWN FUNCTION 09/12/05 Crystal Structure of PA1268 Solved by Sulfur SAD PSEUDOMONAS AERUGINOSA 2.13 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 155 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001206 (835 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1268
Search term: lhpA

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading, Engl.) 2016 Jul;162(7):1232-42
PubMed ID: 27145750
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
FEBS Open Bio 2014 ;4
PubMed ID: 24649405