Pseudomonas aeruginosa PAO1, PA1581 (sdhC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1581
Name
sdhC
Synonym: cybA
Replicon chromosome
Genomic location 1720744 - 1721130 (+ strand)

Cross-References

RefSeq NP_250272.1
GI 15596778
Affymetrix PA1581_sdhC_at
DNASU PaCD00006723
Entrez 881880
GenBank AAG04970.1
INSDC AAG04970.1
NCBI Locus Tag PA1581
protein_id(GenBank) gb|AAG04970.1|AE004586_8|gnl|PseudoCAP|PA1581
TIGR NTL03PA01582
UniParc UPI00000C53F0
UniProtKB Acc Q9I3D7
UniProtKB ID Q9I3D7_PSEAE
UniRef100 UniRef100_W0Z2S2
UniRef50 UniRef50_Q21IV9
UniRef90 UniRef90_A6V7L2

Product

Feature Type CDS
Coding Frame 1
Product Name
succinate dehydrogenase (C subunit)
Product Name Confidence: Class 2
Synonyms succinate dehydrogenase (cytochrome b-556 subunit)
Evidence for Translation
Detected using LC-MS/MS (13.77 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 6.67
Kyte-Doolittle Hydrophobicity Value 0.841
Molecular Weight (kDa) 13.7
Isoelectric Point (pI) 10.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
UBIQUINONE-2 DB08690 DrugBank 5.1.4 P69054 Succinate dehydrogenase cytochrome b556 subunit 55.0 129 3.2e-30
2-[1-METHYLHEXYL]-4,6-DINITROPHENOL DB07671 DrugBank 5.1.4 P69054 Succinate dehydrogenase cytochrome b556 subunit 55.0 129 3.2e-30
Atpenin A5 DB04631 DrugBank 5.1.4 P69054 Succinate dehydrogenase cytochrome b556 subunit 55.0 129 3.2e-30

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 190 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003782 (538 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1581
Search term: sdhC

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Nucleotide sequence encoding the flavoprotein and hydrophobic subunits of the succinate dehydrogenase of Escherichia coli.
Wood D, Darlison MG, Wilde RJ, Guest JR
Biochem J 1984 Sep 1;222(2):519-34
PubMed ID: 6383359
Transcript analysis of the citrate synthase and succinate dehydrogenase genes of Escherichia coli K12.
Wilde RJ, Guest JR
J Gen Microbiol 1986 Dec;132(12):3239-51
PubMed ID: 3309132
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344