Pseudomonas aeruginosa PAO1, PA1590 (braB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1590
Name
braB
Replicon chromosome
Genomic location 1732545 - 1733858 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_250281.1
GI 15596787
Affymetrix PA1590_braB_at
Entrez 882083
GenBank AAG04979.1
INSDC AAG04979.1
NCBI Locus Tag PA1590
protein_id(GenBank) gb|AAG04979.1|AE004587_3|gnl|PseudoCAP|PA1590
TIGR NTL03PA01591
UniParc UPI0000126AB0
UniProtKB Acc P19072
UniProtKB ID BRAB_PSEAE
UniRef100 UniRef100_P19072
UniRef50 UniRef50_P19072
UniRef90 UniRef90_P19072

Product

Feature Type CDS
Coding Frame 1
Product Name
branched chain amino acid transporter
Product Name Confidence: Class 1
Synonyms BraB protein
Evidence for Translation
Charge (pH 7) 2.37
Kyte-Doolittle Hydrophobicity Value 1.095
Molecular Weight (kDa) 45.3
Isoelectric Point (pI) 8.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 131 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003462 (814 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1590
Search term: braB

Human Homologs

References

Immunoaffinity purification and reconstitution of sodium-coupled branched-chain amino acid carrier of Pseudomonas aeruginosa.
Uratani Y
J Biol Chem 1992 Mar 15;267(8):5177-83
PubMed ID: 1544899
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Cloning and nucleotide sequence of the gene braB coding for the sodium-coupled branched-chain amino acid carrier in Pseudomonas aeruginosa PAO.
Hoshino T, Kose K, Uratani Y
Mol Gen Genet 1990 Feb;220(3):461-7
PubMed ID: 2111004