Pseudomonas aeruginosa PAO1, PA1611

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1611
Name
Replicon chromosome
Genomic location 1753607 - 1755562 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250302.1
GI 15596808
Affymetrix PA1611_at
Entrez 881906
GenBank AAG05000.1
INSDC AAG05000.1
NCBI Locus Tag PA1611
protein_id(GenBank) gb|AAG05000.1|AE004589_3|gnl|PseudoCAP|PA1611
TIGR NTL03PA01612
UniParc UPI00000C5408
UniProtKB Acc Q9I3B1
UniProtKB ID Q9I3B1_PSEAE
UniRef100 UniRef100_Q9I3B1
UniRef50 UniRef50_Q9I3B1
UniRef90 UniRef90_Q9I3B1

Product

Feature Type CDS
Coding Frame 1
Product Name
hybrid sensor kinase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -22.98
Kyte-Doolittle Hydrophobicity Value -0.146
Molecular Weight (kDa) 71.5
Isoelectric Point (pI) 4.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7CFW TRANSFERASE 06/29/20 Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with calcium ion coordinated in the active site cleft Pseudomonas aeruginosa 1.31 X-RAY DIFFRACTION 100.0
7C1J TRANSFERASE 05/04/20 Crystal structure of the receiver domain of sensor histidine kinase PA1611 (PA1611REC) from Pseudomonas aeruginosa PAO1 with magnesium ion coordinated in the active site cleft Pseudomonas aeruginosa 1.35 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003759 (493 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1611

Human Homologs

References

A global regulator of secondary metabolite production in Pseudomonas fluorescens Pf-5.
Corbell N, Loper JE
J Bacteriol 1995 Nov;177(21):6230-6
PubMed ID: 7592389
Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1.
Lin CT, Huang YJ, Chu PH, Hsu JL, Huang CH, Peng HL
Res Microbiol 2006 Mar;157(2):169-75
PubMed ID: 16182517