Pseudomonas aeruginosa PAO1, PA1671 (stk1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1671
Name
stk1
Replicon chromosome
Genomic location 1823326 - 1824315 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250362.1
GI 15596868
Affymetrix PA1671_stk1_at
Entrez 883070
GenBank AAG05060.1
INSDC AAG05060.1
NCBI Locus Tag PA1671
protein_id(GenBank) gb|AAG05060.1|AE004594_12|gnl|PseudoCAP|PA1671
TIGR NTL03PA01672
UniParc UPI00000D764E
UniProtKB Acc Q9I354
UniProtKB ID Q9I354_PSEAE
UniRef100 UniRef100_Q9I354
UniRef50 UniRef50_Q9I354
UniRef90 UniRef90_Q9I354

Product

Feature Type CDS
Coding Frame 1
Product Name
Stk1
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.70
Kyte-Doolittle Hydrophobicity Value -0.084
Molecular Weight (kDa) 36.1
Isoelectric Point (pI) 5.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 444 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000073 (1354 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1671
Search term: stk1
Search term: Stk1

Human Homologs

Ensembl 110, assembly GRCh38.p14
mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6858]
E-value: 1.5e-17
Percent Identity: 33.9
Ensembl 110, assembly GRCh38.p14
mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6858]
E-value: 1.5e-17
Percent Identity: 33.9

References

Characterization of a Hank's type serine/threonine kinase and serine/threonine phosphoprotein phosphatase in Pseudomonas aeruginosa.
Mukhopadhyay S, Kapatral V, Xu W, Chakrabarty AM
J Bacteriol 1999 Nov;181(21):6615-22
PubMed ID: 10542161
A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium.
Muñoz-Dorado J, Inouye S, Inouye M
Cell 1991 Nov 29;67(5):995-1006
PubMed ID: 1835671
Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2).
Urabe H, Ogawara H
Gene 1995 Feb 3;153(1):99-104
PubMed ID: 7883195