Pseudomonas aeruginosa PAO1, PA1684

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1684
Name
Replicon chromosome
Genomic location 1833776 - 1834321 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentBiochemical evidence for pathway. 1.13.11.54 occurs when Fe(2+) binds enzyme, 1.13.11.53 occurs when Ni(2+) binds enzyme.

Cross-References

RefSeq NP_250375.1
GI 15596881
Affymetrix PA1684_at
DNASU PaCD00006763
Entrez 877764
GenBank AAG05073.1
INSDC AAG05073.1
NCBI Locus Tag PA1684
protein_id(GenBank) gb|AAG05073.1|AE004595_12|gnl|PseudoCAP|PA1684
TIGR NTL03PA01685
UniParc UPI00000C5445
UniProtKB Acc Q9I341
UniProtKB ID MTND_PSEAE
UniRef100 UniRef100_Q02KH4
UniRef50 UniRef50_Q3KFI8
UniRef90 UniRef90_A6V7A7

Product

Feature Type CDS
Coding Frame 1
Product Name
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase MtnD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.38
Kyte-Doolittle Hydrophobicity Value -0.297
Molecular Weight (kDa) 20.6
Isoelectric Point (pI) 4.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 103 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003706 (525 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1684

Human Homologs

Ensembl 110, assembly GRCh38.p14
acireductone dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:30576]
E-value: 3.1e-12
Percent Identity: 33.6
Ensembl 110, assembly GRCh38.p14
acireductone dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:30576]
E-value: 3.1e-12
Percent Identity: 33.6

References

One protein, two enzymes.
Dai Y, Wensink PC, Abeles RH
J Biol Chem 1999 Jan 15;274(3):1193-5
PubMed ID: 9880484
Bacterial variations on the methionine salvage pathway.
Sekowska A, Dénervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
BMC Microbiol 2004 Mar 4;4:9
PubMed ID: 15102328