Pseudomonas aeruginosa PAO1, PA1708 (popB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1708
Name
popB
Synonym: pepB
Replicon chromosome
Genomic location 1853665 - 1854837 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250399.1
GI 15596905
Affymetrix PA1708_popB_at
Entrez 880867
GenBank AAG05097.1
INSDC AAG05097.1
NCBI Locus Tag PA1708
protein_id(GenBank) gb|AAG05097.1|AE004597_11|gnl|PseudoCAP|PA1708
TIGR NTL03PA01709
UniParc UPI00000C5456
UniProtKB Acc Q9I324
UniProtKB ID Q9I324_PSEAE
UniRef100 UniRef100_Q9I324
UniRef50 UniRef50_Q9I324
UniRef90 UniRef90_Q9I324

Product

Feature Type CDS
Coding Frame 1
Product Name
translocator protein PopB
Product Name Confidence: Class 1
Synonyms PepB
Evidence for Translation
Charge (pH 7) -2.26
Kyte-Doolittle Hydrophobicity Value 0.164
Molecular Weight (kDa) 40.1
Isoelectric Point (pI) 5.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Host Associated
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Extracellular Class 1
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0083
Category T3SS
Evidence
Host Organism
Notes
Reference 11372029

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 7 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003681 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1708
Search term: popB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
YopB and YopD constitute a novel class of Yersinia Yop proteins.
Håkansson S, Bergman T, Vanooteghem JC, Cornelis G, Wolf-Watz H
Infect Immun 1993 Jan;61(1):71-80
PubMed ID: 8418066
Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon.
Yahr TL, Mende-Mueller LM, Friese MB, Frank DW
J Bacteriol 1997 Nov;179(22):7165-8
PubMed ID: 9371466
Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis.
Frithz-Lindsten E, Holmström A, Jacobsson L, Soltani M, Olsson J, Rosqvist R, Forsberg A
Mol Microbiol 1998 Sep;29(5):1155-65
PubMed ID: 9767584