Pseudomonas aeruginosa PAO1, PA1711 (exsE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1711
Name
exsE
Replicon chromosome
Genomic location 1856308 - 1856553 (+ strand)
Transposon Mutants 6 transposon mutants in PAO1
CommentExsE is secreted by the type III secretion system and functions as a regulator of ExsC.

Cross-References

RefSeq NP_250402.1
GI 15596908
Affymetrix PA1711_at
DNASU PaCD00006773
Entrez 880941
GenBank AAG05100.1
INSDC AAG05100.1
NCBI Locus Tag PA1711
protein_id(GenBank) gb|AAG05100.1|AE004597_14|gnl|PseudoCAP|PA1711
TIGR NTL03PA01712
UniParc UPI00000C5458
UniProtKB Acc Q9I322
UniProtKB ID Q9I322_PSEAE
UniRef100 UniRef100_Q9I322
UniRef50 UniRef50_Q9I322
UniRef90 UniRef90_Q9I322

Product

Feature Type CDS
Coding Frame 1
Product Name
ExsE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 2.23
Kyte-Doolittle Hydrophobicity Value -0.637
Molecular Weight (kDa) 8.7
Isoelectric Point (pI) 11.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3KXY CHAPERONE/TRANSCRIPTION INHIBITOR 12/04/09 Crystal Structure of the ExsC-ExsE Complex Pseudomonas aeruginosa 2.804 X-RAY DIFFRACTION 98.5

Virulence Evidence

Source 1
Database VFDB : VF0083
Category T3SS
Evidence
Host Organism
Notes
Reference 11372029

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003678 (293 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1711
Search term: exsE
Search term: ExsE

Human Homologs

References

A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system.
Urbanowski ML, Lykken GL, Yahr TL
Proc Natl Acad Sci U S A 2005 Jul 12;102(28):9930-5
PubMed ID: 15985546
ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa.
Rietsch A, Vallet-Gely I, Dove SL, Mekalanos JJ
Proc Natl Acad Sci U S A 2005 May 31;102(22):8006-11
PubMed ID: 15911752