Pseudomonas aeruginosa PAO1, PA1712 (exsB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1712
Name
exsB
Replicon chromosome
Genomic location 1856562 - 1856975 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250403.1
GI 15596909
Affymetrix PA1712_exsB_at
DNASU PaCD00006774
Entrez 878557
GenBank AAG05101.1
INSDC AAG05101.1
NCBI Locus Tag PA1712
protein_id(GenBank) gb|AAG05101.1|AE004597_15|gnl|PseudoCAP|PA1712
TIGR NTL03PA01713
UniParc UPI000012A39B
UniProtKB Acc P26994
UniProtKB ID EXSB_PSEAE
UniRef100 UniRef100_P26994
UniRef50 UniRef50_P26994
UniRef90 UniRef90_P26994

Product

Feature Type CDS
Coding Frame 1
Product Name
exoenzyme S synthesis protein B
Product Name Confidence: Class 1
Synonyms S synthesis trans-regulatory protein
Evidence for Translation
Charge (pH 7) 3.89
Kyte-Doolittle Hydrophobicity Value -0.032
Molecular Weight (kDa) 15.0
Isoelectric Point (pI) 9.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Outer Membrane Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2YJL LIPID BINDING PROTEIN 05/20/11 Structural characterization of a secretin pilot protein from the type III secretion system (T3SS) of Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.81 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB : VF0083
Category T3SS
Evidence
Host Organism
Notes
Reference 11372029

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003677 (306 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1712
Search term: exsB

Human Homologs

References

Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa.
Frank DW, Iglewski BH
J Bacteriol 1991 Oct;173(20):6460-8
PubMed ID: 1655713
VirG, a Yersinia enterocolitica lipoprotein involved in Ca2+ dependency, is related to exsB of Pseudomonas aeruginosa.
Allaoui A, Scheen R, Lambert de Rouvroit C, Cornelis GR
J Bacteriol 1995 Aug;177(15):4230-7
PubMed ID: 7635810
Structural characterization and membrane localization of ExsB from the type III secretion system (T3SS) of Pseudomonas aeruginosa.
Izoré T, Perdu C, Job V, Attree I, Faudry E, Dessen A
J Mol Biol 2011 Oct 14;413(1):236-46
PubMed ID: 21839744