Pseudomonas aeruginosa PAO1, PA1727 (mucR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1727
Name
mucR
Replicon chromosome
Genomic location 1868706 - 1870763 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentOverexpression of PA1727 increases pellicle formation.

Cross-References

RefSeq NP_250418.1
GI 15596924
Affymetrix PA1727_at
Entrez 881914
GenBank AAG05116.1
INSDC AAG05116.1
NCBI Locus Tag PA1727
protein_id(GenBank) gb|AAG05116.1|AE004599_1|gnl|PseudoCAP|PA1727
TIGR NTL03PA01728
UniParc UPI00000C5464
UniProtKB Acc Q9I310
UniProtKB ID Y1727_PSEAE
UniRef100 UniRef100_Q9I310
UniRef50 UniRef50_Q9I310
UniRef90 UniRef90_Q9I310

Product

Feature Type CDS
Coding Frame 1
Product Name
MucR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -7.59
Kyte-Doolittle Hydrophobicity Value 0.401
Molecular Weight (kDa) 74.4
Isoelectric Point (pI) 6.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5M1T SIGNALING PROTEIN 10/10/16 PaMucR Phosphodiesterase, c-di-GMP complex Pseudomonas aeruginosa 2.27 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003662 (487 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1727
Search term: mucR
Search term: MucR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
MucR, a novel membrane-associated regulator of alginate biosynthesis in Pseudomonas aeruginosa.
Hay ID, Remminghorst U, Rehm BH
Appl Environ Microbiol 2009 Feb;75(4):1110-20
PubMed ID: 19088322