Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1803
|
Name |
lon
Synonym: muc Synonym: lopA Synonym: capR Synonym: deg |
Replicon | chromosome |
Genomic location | 1956227 - 1958623 (+ strand) |
Transposon Mutants | 5 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | "Lon protease is essential for biofilm formation |
RefSeq | NP_250494.1 |
GI | 15597000 |
Affymetrix | PA1803_lon_at |
Entrez | 877926 |
GenBank | AAG05192.1 |
INSDC | AAG05192.1 |
NCBI Locus Tag | PA1803 |
protein_id(GenBank) | gb|AAG05192.1|AE004606_6|gnl|PseudoCAP|PA1803 |
TIGR | NTL03PA01804 |
UniParc | UPI00000C54A4 |
UniProtKB Acc | Q9I2T9 |
UniProtKB ID | Q9I2T9_PSEAE |
UniRef100 | UniRef100_Q9I2T9 |
UniRef50 | UniRef50_P37945 |
UniRef90 | UniRef90_Q9I2T9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Lon protease
|
Synonyms |
CapR protein Atp-dependent protease La |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -9.95 |
Kyte-Doolittle Hydrophobicity Value | -0.279 |
Molecular Weight (kDa) | 88.6 |
Isoelectric Point (pI) | 6.02 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | Lon protease |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Dictyostelium discoideum |
Notes | PAO1 lon mutant exhbited a twofold reduction in the number of amoeba cells required to form a plaque |
Reference | 23145092 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003594 (535 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1803
Search term: lon
Search term: Lon protease
|
Ensembl
110, assembly
GRCh38.p14
|
lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598]
E-value:
6.4e-142
Percent Identity:
37.6
|
Regulatory region of the heat shock-inducible capR (lon) gene: DNA and protein sequences.
Gayda RC, Stephens PE, Hewick R, Schoemaker JM, Dreyer WJ, Markovitz A
J Bacteriol 1985 Apr;162(1):271-5
PubMed ID: 2984174
|
Controlled high-level expression of the lon gene of Escherichia coli allows overproduction of Lon protease.
Thomas CD, Modha J, Razzaq TM, Cullis PM, Rivett AJ
Gene 1993 Dec 22;136(1-2):237-42
PubMed ID: 8294008
|
Redundant in vivo proteolytic activities of Escherichia coli Lon and the ClpYQ (HslUV) protease.
Wu WF, Zhou Y, Gottesman S
J Bacteriol 1999 Jun;181(12):3681-7
PubMed ID: 10368141
|
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P
J Bacteriol 2002 Jan;184(2):363-9
PubMed ID: 11751812
|
Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease.
Takaya A, Tabuchi F, Tsuchiya H, Isogai E, Yamamoto T
J Bacteriol 2008 Jun;190(12):4181-8
PubMed ID: 18408026
|
Role of lon, an ATP-dependent protease homolog, in resistance of Pseudomonas aeruginosa to ciprofloxacin.
Brazas MD, Breidenstein EB, Overhage J, Hancock RE
Antimicrob Agents Chemother 2007 Dec;51(12):4276-83
PubMed ID: 17893152
|
Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.
Breidenstein EB, Khaira BK, Wiegand I, Overhage J, Hancock RE
Antimicrob Agents Chemother 2008 Dec;52(12):4486-91
PubMed ID: 18824609
|
The Lon protease is essential for full virulence in Pseudomonas aeruginosa.
Breidenstein EB, Janot L, Strehmel J, Fernandez L, Taylor PK, Kukavica-Ibrulj I, Gellatly SL, Levesque RC, Overhage J, Hancock RE
PLoS One 2012;7(11):e49123
PubMed ID: 23145092
|