Pseudomonas aeruginosa PAO1, PA1823 (nudC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1823
Name
nudC
Synonym: yjaD
Replicon chromosome
Genomic location 1982705 - 1983541 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_250514.1
GI 15597020
Affymetrix PA1823_at
DNASU PaCD00006823
Entrez 880282
GenBank AAG05212.1
INSDC AAG05212.1
NCBI Locus Tag PA1823
protein_id(GenBank) gb|AAG05212.1|AE004608_11|gnl|PseudoCAP|PA1823
TIGR NTL03PA01824
UniParc UPI00001308ED
UniProtKB Acc O86062
UniProtKB ID NUDC_PSEAE
UniRef100 UniRef100_O86062
UniRef50 UniRef50_Q4KBL2
UniRef90 UniRef90_O86062

Product

Feature Type CDS
Coding Frame 1
Product Name
NudC
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.80
Kyte-Doolittle Hydrophobicity Value -0.187
Molecular Weight (kDa) 31.4
Isoelectric Point (pI) 4.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 341 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003575 (560 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1823
Search term: nudC
Search term: NudC

Human Homologs

Ensembl 86, assembly GRCh38.p7
nudix hydrolase 13 [Source:HGNC Symbol;Acc:HGNC:18827]
E-value: 1.1e-24
Percent Identity: 40.7

Transposon Insertions in PAO1

Type ISlacZ/hah insertion site
Mutant ID UWGC: 2397
Genomic Position 1982853
Position in ORF 149(837)
Reference 14617778

Transposon Insertions in Orthologs

References

NudC Nudix hydrolase from Pseudomonas syringae, but not its counterpart from Pseudomonas aeruginosa, is a novel regulator of intracellular redox balance required for growth, motility and biofilm formation.
Modzelan M, Kujawa M, Głąbski K, Jagura-Burdzy G, Kraszewska E
Mol. Microbiol. 2014 Sep;93(5):867-82
PubMed ID: 24989777