Pseudomonas aeruginosa PAO1, PA1844 (tse1)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA1844
Name	tse1
Replicon	chromosome
Genomic location	2003868 - 2004332 (- strand)
Transposon Mutants	3 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs

Cross-References

RefSeq	NP_250535.1
GI	15597041
Affymetrix	PA1844_at
Entrez	880830
GenBank	AAG05233.1
INSDC	AAG05233.1
NCBI Locus Tag	PA1844
protein_id(GenBank)	gb|AAG05233.1|AE004610_6|gnl|PseudoCAP|PA1844
TIGR	NTL03PA01845
UniParc	UPI00000C54C8
UniProtKB Acc	Q9I2Q1
UniProtKB ID	Q9I2Q1_PSEAE
UniRef100	UniRef100_W0YSD9
UniRef50	UniRef50_A6V6X3
UniRef90	UniRef90_A6V6X3

Product

Feature Type	CDS
Coding Frame	1
Product Name	Tse1 Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	5.03
Kyte-Doolittle Hydrophobicity Value	-0.163
Molecular Weight (kDa)	16.4
Isoelectric Point (pI)	8.80

Subcellular localization

Individual Mappings	Localization Confidence PMID Host Associated Class 1 Extracellular Class 1 Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4F0V	HYDROLASE	05/05/12	Crystal structure of type effector Tse1 from Pseudomonas aeruginousa	Pseudomonas aeruginosa	1.6	X-RAY DIFFRACTION	100.0
4FGE	HYDROLASE	06/04/12	Structure of the effector protein Tse1 from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.7	X-RAY DIFFRACTION	100.0
3VPJ	HYDROLASE/HYDROLASE INHIBITOR	03/04/12	crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa in complex with immune protein Tsi1	Pseudomonas aeruginosa	2.5	X-RAY DIFFRACTION	100.0
3VPI	HYDROLASE	03/04/12	Crystal structure of type VI effector Tse1 from Pseudomonas aeruginosa	Pseudomonas aeruginosa	1.5	X-RAY DIFFRACTION	100.0
4FQB	TOXIN/IMMUNE SYSTEM	06/25/12	crystal structure of toxic effector Tse1 in complex with immune protein Tsi1	Pseudomonas aeruginosa PAO1	2.69	X-RAY DIFFRACTION	100.0
4FGI	HYDROLASE/HYDROLASE INHIBITOR	06/04/12	Structure of the effector - immunity system Tse1 / Tsi1 from Pseudomonas aeruginosa	Pseudomonas aeruginosa	3.2	X-RAY DIFFRACTION	100.0
4FQA	TOXIN	06/25/12	Crystal structure of toxic effector Tse1	Pseudomonas aeruginosa PAO1	2.1	X-RAY DIFFRACTION	100.0
4FGD	HYDROLASE	06/04/12	Structure of the effector protein Tse1 from Pseudomonas aeruginosa, selenomethionine variant	Pseudomonas aeruginosa	2.6	X-RAY DIFFRACTION	100.0
4EOB	HYDROLASE	04/13/12	Structure of the type VI peptidoglycan amidase effector Tse1 from Pseudomonas aeruginosa	Pseudomonas aeruginosa	2.611	X-RAY DIFFRACTION	100.0
4EQ8	UNKNOWN FUNCTION	04/18/12	Crystal structure of PA1844 from Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa	1.392	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003556 (300 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA1844 Search term: tse1 Search term: Tse1

Human Homologs

References

A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD Cell Host Microbe 2010 Jan 21;7(1):25-37 PubMed ID: 20114026

Type VI secretion delivers bacteriolytic effectors to target cells. Russell AB, Hood RD, Bui NK, LeRoux M, Vollmer W, Mougous JD Nature 2011 Jul 20;475(7356):343-7 PubMed ID: 21776080