Pseudomonas aeruginosa PAO1, PA1919 (nrdG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1919
Name
nrdG
Synonym: nrdG
Replicon chromosome
Genomic location 2093444 - 2094142 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_250609.1
GI 15597115
Affymetrix PA1919_at
DNASU PaCD00006863
Entrez 880910
GenBank AAG05307.1
INSDC AAG05307.1
NCBI Locus Tag PA1919
protein_id(GenBank) gb|AAG05307.1|AE004618_1|gnl|PseudoCAP|PA1919
TIGR NTL03PA01919
UniParc UPI00000C5509
UniProtKB Acc Q9I2I5
UniProtKB ID Q9I2I5_PSEAE
UniRef100 UniRef100_Q9I2I5
UniRef50 UniRef50_A6V6P2
UniRef90 UniRef90_A6V6P2

Product

Feature Type CDS
Coding Frame 1
Product Name
class III (anaerobic) ribonucleoside-triphosphate reductase activating protein, 'activase', NrdG
Product Name Confidence: Class 2
Synonyms class III (anaerobic) ribonucleoside-triphosphate reductase activating protein, 'activase', NrdG
Evidence for Translation
Charge (pH 7) 2.51
Kyte-Doolittle Hydrophobicity Value 0.033
Molecular Weight (kDa) 25.7
Isoelectric Point (pI) 8.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 256 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003500 (372 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1919
Search term: nrdG

Human Homologs

References

Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes.
Torrents E, Poplawski A, Sjöberg BM
J Biol Chem 2005 Apr 29;280(17):16571-8
PubMed ID: 15722359
A second-site suppressor of a folding defect functions via interactions with a chaperone network to improve folding and assembly in vivo.
Parent KN, Ranaghan MJ, Teschke CM
Mol Microbiol 2004 Nov;54(4):1036-50
PubMed ID: 15522085