Pseudomonas aeruginosa PAO1, PA1973 (pqqF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1973
Name
pqqF
Replicon chromosome
Genomic location 2155374 - 2157701 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250663.1
GI 15597169
Affymetrix PA1973_pqqF_at
Entrez 878011
GenBank AAG05361.1
INSDC AAG05361.1
NCBI Locus Tag PA1973
protein_id(GenBank) gb|AAG05361.1|AE004623_11|gnl|PseudoCAP|PA1973
TIGR NTL03PA01973
UniParc UPI0000132136
UniProtKB Acc Q9I2D2
UniProtKB ID PQQF_PSEAE
UniRef100 UniRef100_Q9I2D2
UniRef50 UniRef50_Q9I2D2
UniRef90 UniRef90_Q9I2D2

Product

Feature Type CDS
Coding Frame 1
Product Name
pyrroloquinoline quinone biosynthesis protein F
Product Name Confidence: Class 1
Synonyms coenzyme PQQ synthesis protein F
Evidence for Translation
Charge (pH 7) 8.29
Kyte-Doolittle Hydrophobicity Value -0.132
Molecular Weight (kDa) 84.4
Isoelectric Point (pI) 8.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 415 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003460 (500 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1973
Search term: pqqF

Human Homologs

Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0
Ensembl 110, assembly GRCh38.p14
insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381]
E-value: 1.0e-19
Percent Identity: 30.0

References

Synthesis of pyrroloquinoline quinone in vivo and in vitro and detection of an intermediate in the biosynthetic pathway.
Velterop JS, Sellink E, Meulenberg JJ, David S, Bulder I, Postma PW
J Bacteriol 1995 Sep;177(17):5088-98
PubMed ID: 7665488
Tn5-directed cloning of pqq genes from Pseudomonas fluorescens CHA0: mutational inactivation of the genes results in overproduction of the antibiotic pyoluteorin.
Schnider U, Keel C, Voisard C, Défago G, Haas D
Appl Environ Microbiol 1995 Nov;61(11):3856-64
PubMed ID: 8526497