Pseudomonas aeruginosa PAO1, PA2001 (atoB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2001
Name
atoB
Replicon chromosome
Genomic location 2187065 - 2188246 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250691.1
GI 15597197
Affymetrix PA2001_atoB_at
DNASU PaCD00006896
Entrez 879046
GenBank AAG05389.1
INSDC AAG05389.1
NCBI Locus Tag PA2001
protein_id(GenBank) gb|AAG05389.1|AE004626_8|gnl|PseudoCAP|PA2001
TIGR NTL03PA02001
UniParc UPI00000C5550
UniProtKB Acc Q9I2A8
UniProtKB ID ATOB_PSEAE
UniRef100 UniRef100_Q9I2A8
UniRef50 UniRef50_P07097
UniRef90 UniRef90_Q9I2A8

Product

Feature Type CDS
Coding Frame 1
Product Name
acetyl-CoA acetyltransferase
Product Name Confidence: Class 2
Synonyms acetoacetyl-CoA thiolase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.91
Kyte-Doolittle Hydrophobicity Value 0.121
Molecular Weight (kDa) 40.4
Isoelectric Point (pI) 6.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 474 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003434 (530 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2001
Search term: atoB

Human Homologs

Ensembl 110, assembly GRCh38.p14
acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94]
E-value: 1.5e-107
Percent Identity: 52.6

References

Genetic and molecular characterization of the genes involved in short-chain fatty acid degradation in Escherichia coli: the ato system.
Jenkins LS, Nunn WD
J Bacteriol 1987 Jan;169(1):42-52
PubMed ID: 3025185