Pseudomonas aeruginosa PAO1, PA2053 (psCA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2053
Name
psCA2
Replicon chromosome
Genomic location 2246496 - 2247158 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_250743.1
GI 15597249
Affymetrix PA2053_cynT_at
DNASU PaCD00006916
Entrez 878074
GenBank AAG05441.1
INSDC AAG05441.1
NCBI Locus Tag PA2053
protein_id(GenBank) gb|AAG05441.1|AE004631_10|gnl|PseudoCAP|PA2053
TIGR NTL03PA02053
UniParc UPI00000C5576
UniProtKB Acc Q9I262
UniProtKB ID CYNT_PSEAE
UniRef100 UniRef100_Q9I262
UniRef50 UniRef50_Q9I262
UniRef90 UniRef90_Q9I262

Product

Feature Type CDS
Coding Frame 1
Product Name
beta-carbonic anhydrase
Product Name Confidence: Class 1
Synonyms carbonic anhydrase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.03
Kyte-Doolittle Hydrophobicity Value 0.045
Molecular Weight (kDa) 23.4
Isoelectric Point (pI) 6.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 417 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003394 (381 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2053
Search term: psCA2

Human Homologs

References

Carbonic anhydrase in Escherichia coli. A product of the cyn operon.
Guilloton MB, Korte JJ, Lamblin AF, Fuchs JA, Anderson PM
J Biol Chem 1992 Feb 25;267(6):3731-4
PubMed ID: 1740425
Expression of proteins encoded by the Escherichia coli cyn operon: carbon dioxide-enhanced degradation of carbonic anhydrase.
Kozliak EI, Guilloton MB, Gerami-Nejad M, Fuchs JA, Anderson PM
J Bacteriol 1994 Sep;176(18):5711-7
PubMed ID: 8083164
Three functional β-carbonic anhydrases in Pseudomonas aeruginosa PAO1: role in survival in ambient air.
Lotlikar SR, Hnatusko S, Dickenson NE, Choudhari SP, Picking WL, Patrauchan MA
Microbiology (Reading, Engl.) 2013 Aug;159(Pt 8):1748-59
PubMed ID: 23728627