Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2081
|
Name |
kynB
|
Replicon | chromosome |
Genomic location | 2290339 - 2290980 (- strand) |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Comment | KynB is involved in the aerobic degradation of L-tryptophan to anthranilate. This form of kynurenine formamidase (KFA) is nonhomologous to the eukarytic KFA characterized in mice and belongs to a different class of Zn-dependent hydrolases |
RefSeq | NP_250771.1 |
GI | 15597277 |
Affymetrix | PA2081_at |
DNASU | PaCD00006922 |
Entrez | 878591 |
GenBank | AAG05469.1 |
INSDC | AAG05469.1 |
NCBI Locus Tag | PA2081 |
protein_id(GenBank) | gb|AAG05469.1|AE004635_7|gnl|PseudoCAP|PA2081 |
TIGR | NTL03PA02081 |
UniParc | UPI00000C5590 |
UniProtKB Acc | Q9I234 |
UniProtKB ID | KYNB_PSEAE |
UniRef100 | UniRef100_Q9I234 |
UniRef50 | UniRef50_P0C8P4 |
UniRef90 | UniRef90_Q9I234 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
kynurenine formamidase, KynB
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -8.75 |
Kyte-Doolittle Hydrophobicity Value | -0.060 |
Molecular Weight (kDa) | 23.2 |
Isoelectric Point (pI) | 5.21 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4COB | HYDROLASE | 01/28/14 | Crystal structure kynurenine formamidase from Pseudomonas aeruginosa | PSEUDOMONAS AERUGINOSA | 2.37 | X-RAY DIFFRACTION | 99.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 193 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003374 (350 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2081
Search term: kynB
Search term: kynurenine formamidase, KynB
|
Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase.
Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A
FEMS Microbiol Lett 2003 Oct 24;227(2):219-27
PubMed ID: 14592712
|