Pseudomonas aeruginosa PAO1, PA2196

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2196
Name
Replicon chromosome
Genomic location 2415661 - 2416245 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 19 transposon mutants in orthologs

Cross-References

RefSeq NP_250886.1
GI 15597392
Affymetrix PA2196_at
Entrez 881967
GenBank AAG05584.1
INSDC AAG05584.1
NCBI Locus Tag PA2196
protein_id(GenBank) gb|AAG05584.1|AE004646_5|gnl|PseudoCAP|PA2196
TIGR NTL03PA02196
UniParc UPI00000C55FE
UniProtKB Acc Q9I1S1
UniProtKB ID Q9I1S1_PSEAE
UniRef100 UniRef100_W0YRR7
UniRef50 UniRef50_A6V5X5
UniRef90 UniRef90_A6V5X5

Product

Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.20
Kyte-Doolittle Hydrophobicity Value -0.292
Molecular Weight (kDa) 21.7
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3RD3 TRANSCRIPTION 03/31/11 Structure of Pseudomonas aeruginosa transcriptional regulator PA2196 Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 100.0
4L62 TRANSCRIPTION/DNA 06/11/13 Crystal Structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT 2.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 296 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000241 (6008 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2196

Human Homologs

References

Crystal structure of Pseudomonas aeruginosa transcriptional regulator PA2196 bound to its operator DNA.
Kim Y, Kang Y, Choe J
Biochem Biophys Res Commun 2013 Oct 18;440(2):317-21
PubMed ID: 24070609