Pseudomonas aeruginosa PAO1, PA2273 (soxR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2273
Name
soxR
Synonym: soxR
Replicon chromosome
Genomic location 2503425 - 2503895 (- strand)

Cross-References

RefSeq NP_250963.1
GI 15597469
Affymetrix PA2273_at
Entrez 882298
GenBank AAG05661.1
INSDC AAG05661.1
NCBI Locus Tag PA2273
protein_id(GenBank) gb|AAG05661.1|AE004653_4|gnl|PseudoCAP|PA2273
TIGR NTL03PA02273
UniParc UPI0000135D19
UniProtKB Acc Q51506
UniProtKB ID SOXR_PSEAE
UniRef100 UniRef100_Q51506
UniRef50 UniRef50_Q51506
UniRef90 UniRef90_Q51506

Product

Feature Type CDS
Coding Frame 1
Product Name
SoxR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.56
Kyte-Doolittle Hydrophobicity Value -0.329
Molecular Weight (kDa) 17.0
Isoelectric Point (pI) 8.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
Pseudomonas aeruginosa soxR SoxR is a redox-sensitive transcriptional activator that induces expression of a small regulon that includes the RND efflux pump-encoding operon mexGHI-opmD. SoxR was shown to be activated by pyocyanin. [PMID:15845502, PMID:16879411, PMID:27274079] ARO:3004107 protein homolog model Perfect 309.7 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse pulmonary Infection model
Reference 15845502

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 267 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003220 (458 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2273
Search term: soxR
Search term: SoxR

Human Homologs

References

Activation of SoxR-dependent transcription in Pseudomonas aeruginosa.
Kobayashi K, Tagawa S
J Biochem 2004 Nov;136(5):607-15
PubMed ID: 15632300
Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon.
Amábile-Cuevas CF, Demple B
Nucleic Acids Res 1991 Aug 25;19(16):4479-84
PubMed ID: 1653416
An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.
Hidalgo E, Demple B
EMBO J 1994 Jan 1;13(1):138-46
PubMed ID: 8306957