Pseudomonas aeruginosa PAO1, PA2280

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2280
Name
Synonym: arsH
Replicon chromosome
Genomic location 2508775 - 2509467 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_250970.1
GI 15597476
Affymetrix PA2280_at
DNASU PaCD00007004
Entrez 878504
GenBank AAG05668.1
INSDC AAG05668.1
NCBI Locus Tag PA2280
protein_id(GenBank) gb|AAG05668.1|AE004653_11|gnl|PseudoCAP|PA2280
TIGR NTL03PA02280
UniParc UPI00000C5642
UniProtKB Acc Q9I1J5
UniProtKB ID Q9I1J5_PSEAE
UniRef100 UniRef100_W0YPM5
UniRef50 UniRef50_P74312
UniRef90 UniRef90_A6V5I6

Product

Feature Type CDS
Coding Frame 1
Product Name
oxidoreductase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.66
Kyte-Doolittle Hydrophobicity Value -0.322
Molecular Weight (kDa) 26.2
Isoelectric Point (pI) 7.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 157 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003216 (473 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2280
Search term: oxidoreductase

Human Homologs

References

Virulence and arsenic resistance in Yersiniae.
Neyt C, Iriarte M, Thi VH, Cornelis GR
J Bacteriol 1997 Feb;179(3):612-9
PubMed ID: 9006011
Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from P. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes.
Ryan A, Kaplan E, Nebel JC, Polycarpou E, Crescente V, Lowe E, Preston GM, Sim E
PLoS One 2014;9(6):e98551
PubMed ID: 24915188