Pseudomonas aeruginosa PAO1, PA2404 (fpvH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2404
Name
fpvH
Replicon chromosome
Genomic location 2688705 - 2689244 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentPart ABC transporter complex FpvWXYZCDEF coded by operons fpvWXYZCDEF and fpvF.

Cross-References

RefSeq NP_251094.1
GI 15597600
Affymetrix PA2404_at
DNASU PaCD00007044
Entrez 879521
GenBank AAG05792.1
INSDC AAG05792.1
NCBI Locus Tag PA2404
protein_id(GenBank) gb|AAG05792.1|AE004668_2|gnl|PseudoCAP|PA2404
TIGR NTL03PA02404
UniParc UPI00000C56B4
UniProtKB Acc Q9I177
UniProtKB ID Q9I177_PSEAE
UniRef100 UniRef100_Q9I177
UniRef50 UniRef50_G8Q017
UniRef90 UniRef90_W0Z6M8

Product

Feature Type CDS
Coding Frame 1
Product Name
FpvH
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 6.65
Kyte-Doolittle Hydrophobicity Value -0.060
Molecular Weight (kDa) 19.9
Isoelectric Point (pI) 10.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003128 (484 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2404
Search term: fpvH
Search term: FpvH

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH.
Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ
ACS Chem Biol 2017 Apr 21;12(4):1056-1065
PubMed ID: 28192658
The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions.
Gao L, Guo Z, Wang Y, Wang Y, Wang K, Li B, Shen L
J Membr Biol 2018 Feb;251(1):91-104
PubMed ID: 28975384