Pseudomonas aeruginosa PAO1, PA2408 (fpvD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2408
Name	fpvD
Replicon	chromosome
Genomic location	2691110 - 2691865 (+ strand)
Transposon Mutants	1 transposon mutants in PAO1
Comment	Part ABC transporter complex FpvWXYZCDEF coded by operons fpvWXYZCDEF and fpvF.

Cross-References

RefSeq	NP_251098.1
GI	15597604
Affymetrix	PA2408_at
Entrez	879637
GenBank	AAG05796.1
INSDC	AAG05796.1
NCBI Locus Tag	PA2408
protein_id(GenBank)	gb|AAG05796.1|AE004668_6|gnl|PseudoCAP|PA2408
TIGR	NTL03PA02408
UniParc	UPI00000C56B7
UniProtKB Acc	Q9I173
UniProtKB ID	Q9I173_PSEAE
UniRef100	UniRef100_Q9I173
UniRef50	UniRef50_D7HYC2
UniRef90	UniRef90_Q9I173

Product

Feature Type	CDS
Coding Frame	1
Product Name	FpvD Product Name Confidence: Class 1
Synonyms	probable ATP-binding component of ABC transporter
Evidence for Translation
Charge (pH 7)	3.84
Kyte-Doolittle Hydrophobicity Value	-0.000
Molecular Weight (kDa)	27.1
Isoelectric Point (pI)	8.68

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543 Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003124 (478 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2408 Search term: fpvD Search term: FpvD

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000355637 ATP binding cassette subfamily B member 10 [Source:HGNC Symbol;Acc:HGNC:41] E-value: 2.5e-07 Percent Identity: 29.6

References

Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH. Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ ACS Chem Biol 2017 Apr 21;12(4):1056-1065 PubMed ID: 28192658

An ABC transporter with two periplasmic binding proteins involved in iron acquisition in Pseudomonas aeruginosa. Brillet K, Ruffenach F, Adams H, Journet L, Gasser V, Hoegy F, Guillon L, Hannauer M, Page A, Schalk IJ ACS Chem Biol 2012 Dec 21;7(12):2036-45 PubMed ID: 23009327

The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions. Gao L, Guo Z, Wang Y, Wang Y, Wang K, Li B, Shen L J Membr Biol 2018 Feb;251(1):91-104 PubMed ID: 28975384