Pseudomonas aeruginosa PAO1, PA2410 (fpvF)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2410
Name	fpvF
Replicon	chromosome
Genomic location	2692764 - 2693681 (+ strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	1 transposon mutants in orthologs
Comment	Part ABC transporter complex FpvWXYZCDEF coded by operons fpvWXYZCDEF and fpvF.

Cross-References

RefSeq	NP_251100.1
GI	15597606
Affymetrix	PA2410_at
Entrez	879581
GenBank	AAG05798.1
INSDC	AAG05798.1
NCBI Locus Tag	PA2410
protein_id(GenBank)	gb|AAG05798.1|AE004668_8|gnl|PseudoCAP|PA2410
TIGR	NTL03PA02410
UniParc	UPI00000C56B9
UniProtKB Acc	Q9I171
UniProtKB ID	Q9I171_PSEAE
UniRef100	UniRef100_Q9I171
UniRef50	UniRef50_Q88GC0
UniRef90	UniRef90_Q9I171

Product

Feature Type	CDS
Coding Frame	1
Product Name	FpvF Product Name Confidence: Class 1
Synonyms	hypothetical protein
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-6.85
Kyte-Doolittle Hydrophobicity Value	0.145
Molecular Weight (kDa)	31.7
Isoelectric Point (pI)	5.00

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 18 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003122 (477 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2410 Search term: fpvF Search term: FpvF

Human Homologs

References

Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH. Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ ACS Chem Biol 2017 Apr 21;12(4):1056-1065 PubMed ID: 28192658

An ABC transporter with two periplasmic binding proteins involved in iron acquisition in Pseudomonas aeruginosa. Brillet K, Ruffenach F, Adams H, Journet L, Gasser V, Hoegy F, Guillon L, Hannauer M, Page A, Schalk IJ ACS Chem Biol 2012 Dec 21;7(12):2036-45 PubMed ID: 23009327

The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions. Gao L, Guo Z, Wang Y, Wang Y, Wang K, Li B, Shen L J Membr Biol 2018 Feb;251(1):91-104 PubMed ID: 28975384