Pseudomonas aeruginosa PAO1, PA2491 (mexS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA2491
Name
mexS
Replicon chromosome
Genomic location 2806350 - 2807369 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_251181.1
GI 15597687
Affymetrix PA2491_at
Entrez 880416
GenBank AAG05879.1
INSDC AAG05879.1
NCBI Locus Tag PA2491
protein_id(GenBank) gb|AAG05879.1|AE004676_11|gnl|PseudoCAP|PA2491
TIGR NTL03PA02491
UniParc UPI00000C5701
UniProtKB Acc Q9I0Z1
UniProtKB ID Q9I0Z1_PSEAE
UniRef100 UniRef100_Q9I0Z1
UniRef50 UniRef50_Q9I0Z1
UniRef90 UniRef90_Q9I0Z1

Product

Feature Type CDS
Coding Frame 1
Product Name
MexS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.98
Kyte-Doolittle Hydrophobicity Value 0.055
Molecular Weight (kDa) 36.8
Isoelectric Point (pI) 5.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexS MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. ARO:3000813 protein overexpression model Strict 672.5 99.71 3.0.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 495 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003064 (541 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2491
Search term: mexS
Search term: MexS

Human Homologs

Ensembl 97, assembly GRCh38.p12
vesicle amine transport 1 [Source:HGNC Symbol;Acc:HGNC:16919]
E-value: 4.0e-25
Percent Identity: 28.2

References

Mutations in PA2491 (mexS) promote MexT-dependent mexEF-oprN expression and multidrug resistance in a clinical strain of Pseudomonas aeruginosa.
Sobel ML, Neshat S, Poole K
J. Bacteriol. 2005 Feb;187(4):1246-53
PubMed ID: 15687188