Pseudomonas aeruginosa PAO1, PA2532 (tpx)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2532
Name
tpx
Replicon chromosome
Genomic location 2859777 - 2860274 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251222.1
GI 15597728
Affymetrix PA2532_tpx_at
Entrez 880363
GenBank AAG05920.1
INSDC AAG05920.1
NCBI Locus Tag PA2532
protein_id(GenBank) gb|AAG05920.1|AE004681_2|gnl|PseudoCAP|PA2532
TIGR NTL03PA02532
UniParc UPI000013729B
UniProtKB Acc P57668
UniProtKB ID TPX_PSEAE
UniRef100 UniRef100_P57668
UniRef50 UniRef50_A5F3A2
UniRef90 UniRef90_P57668

Product

Feature Type CDS
Coding Frame 1
Product Name
thiol peroxidase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Charge (pH 7) -2.86
Kyte-Doolittle Hydrophobicity Value 0.207
Molecular Weight (kDa) 17.2
Isoelectric Point (pI) 4.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 333 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003035 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2532
Search term: tpx
Search term: thiol peroxidase

Human Homologs

References

Thioredoxin-linked "thiol peroxidase" from periplasmic space of Escherichia coli.
Cha MK, Kim HK, Kim IH
J Biol Chem 1995 Dec 1;270(48):28635-41
PubMed ID: 7499381
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142
Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation.
Somprasong N, Jittawuttipoka T, Duang-Nkern J, Romsang A, Chaiyen P, Schweizer HP, Vattanaviboon P, Mongkolsuk S
J Bacteriol 2012 Aug;194(15):3904-12
PubMed ID: 22609922