Pseudomonas aeruginosa PAO1, PA2591 (vqsR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2591
Name
vqsR
Replicon chromosome
Genomic location 2933582 - 2934388 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251281.1
GI 15597787
Affymetrix PA2591_at
Entrez 878740
GenBank AAG05979.1
INSDC AAG05979.1
NCBI Locus Tag PA2591
protein_id(GenBank) gb|AAG05979.1|AE004688_1|gnl|PseudoCAP|PA2591
TIGR NTL03PA02591
UniParc UPI00000C5757
UniProtKB Acc Q9I0P6
UniProtKB ID Q9I0P6_PSEAE
UniRef100 UniRef100_W0YT10
UniRef50 UniRef50_A6V4I6
UniRef90 UniRef90_W0YT10

Product

Feature Type CDS
Coding Frame 1
Product Name
VqsR
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.13
Kyte-Doolittle Hydrophobicity Value -0.102
Molecular Weight (kDa) 30.6
Isoelectric Point (pI) 5.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5XHX TRANSCRIPTION 04/24/17 Crystal structure of VqsR LBD domain from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 301 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002957 (304 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2591
Search term: vqsR
Search term: VqsR

Human Homologs

References

Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa.
Juhas M, Wiehlmann L, Huber B, Jordan D, Lauber J, Salunkhe P, Limpert AS, von Götz F, Steinmetz I, Eberl L, Tümmler B
Microbiology (Reading) 2004 Apr;150(Pt 4):831-841
PubMed ID: 15073293
The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression.
Liang H, Deng X, Ji Q, Sun F, Shen T, He C
J Bacteriol 2012 Jun;194(12):3098-108
PubMed ID: 22505688