Pseudomonas aeruginosa PAO1, PA2602

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2602
Name
Synonym: thiol dioxygenase
Replicon chromosome
Genomic location 2945264 - 2945869 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_251292.1
GI 15597798
Affymetrix PA2602_at
DNASU PaCD00007120
Entrez 882308
GenBank AAG05990.1
INSDC AAG05990.1
NCBI Locus Tag PA2602
protein_id(GenBank) gb|AAG05990.1|AE004689_2|gnl|PseudoCAP|PA2602
TIGR NTL03PA02602
UniParc UPI00000C5762
UniProtKB Acc Q9I0N5
UniProtKB ID Q9I0N5_PSEAE
UniRef100 UniRef100_Q9I0N5
UniRef50 UniRef50_Q9I0N5
UniRef90 UniRef90_Q9I0N5

Product

Feature Type CDS
Coding Frame 1
Product Name
3-mercaptopropionate dioxygenase
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -2.11
Kyte-Doolittle Hydrophobicity Value -0.438
Molecular Weight (kDa) 22.5
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3USS OXIDOREDUCTASE 11/23/11 Crystal structure of Cysteine dioxygenase from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.7 X-RAY DIFFRACTION 100.0
4WVZ OXIDOREDUCTASE 11/09/14 Crystal structure of artificial crosslinked thiol dioxygenase G95C variant from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.09 X-RAY DIFFRACTION 99.5
4TLF OXIDOREDUCTASE 05/29/14 Crystal structure of Thiol dioxygenase from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.137 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 71 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002949 (389 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2602

Human Homologs

References

The cysteine dioxygenase homologue from Pseudomonas aeruginosa is a 3-mercaptopropionate dioxygenase.
Tchesnokov EP, Fellner M, Siakkou E, Kleffmann T, Martin LW, Aloi S, Lamont IL, Wilbanks SM, Jameson GN
J Biol Chem 2015 Oct 2;290(40):24424-37
PubMed ID: 26272617