Pseudomonas aeruginosa PAO1, PA2663 (ppyR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2663
Name
ppyR
Replicon chromosome
Genomic location 3012280 - 3012537 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251353.1
GI 15597859
Affymetrix PA2663_at
DNASU PaCD00007147
Entrez 882372
GenBank AAG06051.1
INSDC AAG06051.1
NCBI Locus Tag PA2663
protein_id(GenBank) gb|AAG06051.1|AE004695_4|gnl|PseudoCAP|PA2663
TIGR NTL03PA02663
UniParc UPI00000C5797
UniProtKB Acc Q9I0H5
UniProtKB ID Q9I0H5_PSEAE
UniRef100 UniRef100_W0YQW6
UniRef50 UniRef50_W0YQW6
UniRef90 UniRef90_W0YQW6

Product

Feature Type CDS
Coding Frame 1
Product Name
psl and pyoverdine operon regulator, PpyR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 6.36
Kyte-Doolittle Hydrophobicity Value 0.885
Molecular Weight (kDa) 9.3
Isoelectric Point (pI) 10.27

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Hordeum vulgare
Notes
Infection model Barley seed pathogenicity assay
Reference 21261818

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002894 (346 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2663
Search term: ppyR

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
PA2663 (PpyR) increases biofilm formation in Pseudomonas aeruginosa PAO1 through the psl operon and stimulates virulence and quorum-sensing phenotypes.
Attila C, Ueda A, Wood TK
Appl Microbiol Biotechnol 2008 Feb;78(2):293-307
PubMed ID: 18157527