Pseudomonas aeruginosa PAO1, PA2665 (fhpR )

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2665
Name
fhpR 
Synonym: ygaA
Replicon chromosome
Genomic location 3013928 - 3015481 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251355.1
GI 15597861
Affymetrix PA2665_at
Entrez 882374
GenBank AAG06053.1
INSDC AAG06053.1
NCBI Locus Tag PA2665
protein_id(GenBank) gb|AAG06053.1|AE004695_6|gnl|PseudoCAP|PA2665
TIGR NTL03PA02665
UniParc UPI00000C5799
UniProtKB Acc Q9I0H3
UniProtKB ID Q9I0H3_PSEAE
UniRef100 UniRef100_W0YRX1
UniRef50 UniRef50_G8QAY7
UniRef90 UniRef90_W0YRX1

Product

Feature Type CDS
Coding Frame 1
Product Name
Transcriptional activator of P. aeruginosa flavohemoglobin, FhpR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.05
Kyte-Doolittle Hydrophobicity Value -0.320
Molecular Weight (kDa) 57.4
Isoelectric Point (pI) 6.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 452 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002892 (524 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2665
Search term: fhpR 

Human Homologs

References

Induction of Pseudomonas aeruginosa fhp and fhpR by reactive oxygen species.
Koskenkorva-Frank TS, Kallio PT
Can J Microbiol 2009 Jun;55(6):657-63
PubMed ID: 19767835
Transcriptional regulation of the flavohemoglobin gene for aerobic nitric oxide detoxification by the second nitric oxide-responsive regulator of Pseudomonas aeruginosa.
Arai H, Hayashi M, Kuroi A, Ishii M, Igarashi Y
J Bacteriol 2005 Jun;187(12):3960-8
PubMed ID: 15937158
Transcriptional activity of Pseudomonas aeruginosa fhp promoter is dependent on two regulators in addition to FhpR.
Koskenkorva T, Aro-Kärkkäinen N, Bachmann D, Arai H, Frey AD, Kallio PT
Arch Microbiol 2008 Apr;189(4):385-96
PubMed ID: 18043907