Pseudomonas aeruginosa PAO1, PA2667 (mvaU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2667
Name
mvaU
Replicon chromosome
Genomic location 3016246 - 3016599 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251357.1
GI 15597863
Affymetrix PA2667_at
DNASU PaCD00007149
Entrez 882376
GenBank AAG06055.1
INSDC AAG06055.1
NCBI Locus Tag PA2667
protein_id(GenBank) gb|AAG06055.1|AE004695_8|gnl|PseudoCAP|PA2667
TIGR NTL03PA02667
UniParc UPI00000C579B
UniProtKB Acc Q9I0H1
UniProtKB ID Q9I0H1_PSEAE
UniRef100 UniRef100_W0YTT1
UniRef50 UniRef50_A6V4B1
UniRef90 UniRef90_A6V4B1

Product

Feature Type CDS
Coding Frame 1
Product Name
MvaU
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by iTRAQ (PMID:21863142).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.47
Kyte-Doolittle Hydrophobicity Value -0.696
Molecular Weight (kDa) 13.4
Isoelectric Point (pI) 10.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002890 (507 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2667
Search term: mvaU
Search term: MvaU

Human Homologs

References

Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon.
Rosenthal RS, Rodwell VW
Protein Sci 1998 Jan;7(1):178-84
PubMed ID: 9514272
The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1.
Li C, Wally H, Miller SJ, Lu CD
J Bacteriol 2009 Oct;191(20):6211-8
PubMed ID: 19684136
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142