Pseudomonas aeruginosa PAO1, PA2684 (tse5)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2684
Name	tse5 Synonym: rhsP1 Synonym: rhs
Replicon	chromosome
Genomic location	3031749 - 3035702 (- strand)
Transposon Mutants	4 transposon mutants in PAO1
Transposon Mutants in orthologs	4 transposon mutants in orthologs
Comment	The associated immunity gene is rhsI1
Comment	The associated immunity gene is rhsI1

Cross-References

RefSeq	NP_251374.1
GI	15597880
Affymetrix	PA2684_at
Entrez	879129
GenBank	AAG06072.1
INSDC	AAG06072.1
NCBI Locus Tag	PA2684
protein_id(GenBank)	gb|AAG06072.1|AE004696_6|gnl|PseudoCAP|PA2684
TIGR	NTL03PA02684
UniParc	UPI00000C57AC
UniProtKB Acc	Q9I0F4
UniProtKB ID	Q9I0F4_PSEAE
UniRef100	UniRef100_Q9I0F4
UniRef50	UniRef50_Q02NH6
UniRef90	UniRef90_Q02NH6

Product

Feature Type	CDS
Coding Frame	1
Product Name	Tse5 Product Name Confidence: Class 1
Synonyms	RhsP1
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-7.05
Kyte-Doolittle Hydrophobicity Value	-0.549
Molecular Weight (kDa)	145.8
Isoelectric Point (pI)	6.58

Subcellular localization

Individual Mappings	Localization Confidence PMID Outer Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 196 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000092 (1670 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2684 Search term: tse5 Search term: Tse5

Human Homologs

References

Rhs elements of Escherichia coli: a family of genetic composites each encoding a large mosaic protein. Hill CW, Sandt CH, Vlazny DA Mol Microbiol 1994 Jun;12(6):865-71 PubMed ID: 7934896

Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli. Wang YD, Zhao S, Hill CW J Bacteriol 1998 Aug;180(16):4102-10 PubMed ID: 9696756

The VgrG proteins are "à la carte" delivery systems for bacterial type VI effectors. Hachani A, Allsopp LP, Oduko Y, Filloux A J Biol Chem 2014 Jun 20;289(25):17872-84 PubMed ID: 24794869

Genetically distinct pathways guide effector export through the type VI secretion system. Whitney JC, Beck CM, Goo YA, Russell AB, Harding BN, De Leon JA, Cunningham DA, Tran BQ, Low DA, Goodlett DR, Hayes CS, Mougous JD Mol Microbiol 2014 May;92(3):529-42 PubMed ID: 24589350