Pseudomonas aeruginosa PAO1, PA2783 (mep72)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2783
Name
mep72
Replicon chromosome
Genomic location 3139748 - 3141547 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251473.1
GI 15597979
Affymetrix PA2783_at
Entrez 878794
GenBank AAG06171.1
INSDC AAG06171.1
NCBI Locus Tag PA2783
protein_id(GenBank) gb|AAG06171.1|AE004706_1|gnl|PseudoCAP|PA2783
TIGR NTL03PA02783
UniParc UPI00000C5803
UniProtKB Acc Q9I060
UniProtKB ID Q9I060_PSEAE
UniRef100 UniRef100_Q9I060
UniRef50 UniRef50_A4XZZ3
UniRef90 UniRef90_Q9I060

Product

Feature Type CDS
Coding Frame 1
Product Name
Mep72
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 8.96
Kyte-Doolittle Hydrophobicity Value -0.358
Molecular Weight (kDa) 65.0
Isoelectric Point (pI) 8.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
mass spectrometry evidence used in manual assertion
Outer Membrane Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 20 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002786 (297 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2783
Search term: mep72
Search term: Mep72

Human Homologs

References

Characterization of the Pseudomonas aeruginosa metalloendopeptidase, Mep72, a member of the Vfr regulon.
Balyimez A, Colmer-Hamood JA, San Francisco M, Hamood AN
BMC Microbiol 2013 Nov 27;13:269
PubMed ID: 24279383
Mep72, a metzincin protease that is preferentially secreted by biofilms of Pseudomonas aeruginosa.
Passmore IJ, Nishikawa K, Lilley KS, Bowden SD, Chung JC, Welch M
J Bacteriol 2015 Feb 15;197(4):762-73
PubMed ID: 25488299