Pseudomonas aeruginosa PAO1, PA2808 (ptrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2808
Name
ptrA
Synonym: ptrA
Replicon chromosome
Genomic location 3162388 - 3162579 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentExpression of the ptrA gene is activated by CopS (PA2810) and CopR (PA2809) in response to high copper stress.

Cross-References

RefSeq NP_251498.1
GI 15598004
Affymetrix PA2808_i_at
Entrez 878671
GenBank AAG06196.1
INSDC AAG06196.1
NCBI Locus Tag PA2808
protein_id(GenBank) gb|AAG06196.1|AE004708_2|gnl|PseudoCAP|PA2808
TIGR NTL03PA02808
UniParc UPI00000C581A
UniProtKB Acc Q9I035
UniProtKB ID Q9I035_PSEAE
UniRef100 UniRef100_W0YU93
UniRef50 UniRef50_W0YU93
UniRef90 UniRef90_W0YU93

Product

Feature Type CDS
Coding Frame 1
Product Name
Pseudomonas type III repressor A
Product Name Confidence: Class 1
Synonyms New product name: repressor, PtrA
Evidence for Translation
Charge (pH 7) 2.19
Kyte-Doolittle Hydrophobicity Value -0.211
Molecular Weight (kDa) 6.8
Isoelectric Point (pI) 9.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Periplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002761 (298 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2808
Search term: ptrA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
An in vivo inducible gene of Pseudomonas aeruginosa encodes an anti-ExsA to suppress the type III secretion system.
Ha UH, Kim J, Badrane H, Jia J, Baker HV, Wu D, Jin S
Mol Microbiol 2004 Oct;54(2):307-20
PubMed ID: 15469505
PtrA is a periplasmic protein involved in Cu tolerance in Pseudomonas aeruginosa.
Elsen S, Ragno M, Attree I
J Bacteriol 2011 Jul;193(13):3376-8
PubMed ID: 21531801