Pseudomonas aeruginosa PAO1, PA2886 (atuA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2886
Name	atuA
Replicon	chromosome
Genomic location	3237836 - 3239638 (+ strand)
Transposon Mutants	2 transposon mutants in PAO1
Transposon Mutants in orthologs	2 transposon mutants in orthologs
Comment	Knock out in atuA (and constitutive expression of downstream genes from a lac promotor) resulted in negative phenotype on citronellol. 3-hydroxy-3-isohexenylglutaryl-CoA:acetate- lyase is only missing enzyme of the Atu pathway; all other functions can be covered by the other atu genes.

Cross-References

RefSeq	NP_251576.1
GI	15598082
Affymetrix	PA2886_at
Entrez	882608
GenBank	AAG06274.1
INSDC	AAG06274.1
NCBI Locus Tag	PA2886
protein_id(GenBank)	gb|AAG06274.1|AE004714_11|gnl|PseudoCAP|PA2886
TIGR	NTL03PA02886
UniParc	UPI00000C5861
UniProtKB Acc	Q9HZW1
UniProtKB ID	Q9HZW1_PSEAE
UniRef100	UniRef100_Q9HZW1
UniRef50	UniRef50_Q9HZW1
UniRef90	UniRef90_Q9HZW1

Product

Feature Type	CDS
Coding Frame	1
Product Name	expressed protein with apparent function in citronellol catabolism Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7)	-14.66
Kyte-Doolittle Hydrophobicity Value	0.030
Molecular Weight (kDa)	64.4
Isoelectric Point (pI)	5.05

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 112 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG002687 (443 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2886 Search term: atuA Search term: expressed protein with apparent function in citronellol catabolism

Human Homologs

References

Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa. Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D Appl Environ Microbiol 2006 Jul;72(7):4819-28 PubMed ID: 16820476