Pseudomonas aeruginosa PAO1, PA2888 (atuC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2888
Name
atuC
Replicon chromosome
Genomic location 3240591 - 3242207 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251578.1
GI 15598084
Affymetrix PA2888_at
Entrez 882701
GenBank AAG06276.1
INSDC AAG06276.1
NCBI Locus Tag PA2888
protein_id(GenBank) gb|AAG06276.1|AE004715_2|gnl|PseudoCAP|PA2888
TIGR NTL03PA02888
UniParc UPI00000C5863
UniProtKB Acc Q9HZV9
UniProtKB ID Q9HZV9_PSEAE
UniRef100 UniRef100_W0YVU4
UniRef50 UniRef50_Q4K8Z5
UniRef90 UniRef90_A0A024HJJ5

Product

Feature Type CDS
Coding Frame 1
Product Name
geranyl-CoA carboxylase, beta-subunit
Product Name Confidence: Class 1
Synonyms geranyl-coenzymeA-carboxylase subunit, AtuC
Evidence for Translation
Charge (pH 7) -2.23
Kyte-Doolittle Hydrophobicity Value -0.127
Molecular Weight (kDa) 57.3
Isoelectric Point (pI) 6.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5IKL LIGASE 03/03/16 Crystal structure of P. aeruginosa geranyl-CoA carboxylase (GCC), beta subunit Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.4 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 421 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002685 (404 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2888
Search term: atuC

Human Homologs

Ensembl 110, assembly GRCh38.p14
methylcrotonyl-CoA carboxylase subunit 2 [Source:HGNC Symbol;Acc:HGNC:6937]
E-value: 4.2e-129
Percent Identity: 44.7

References

Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl Environ Microbiol 2006 Jul;72(7):4819-28
PubMed ID: 16820476