Pseudomonas aeruginosa PAO1, PA2892 (atuG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2892
Name
atuG
Replicon chromosome
Genomic location 3246382 - 3247206 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentGene product not essential for growth on citronellol (shown by insertion mutagenesis) but protein is expressed (confirmed by SDS-PAGE).

Cross-References

RefSeq NP_251582.1
GI 15598088
Affymetrix PA2892_at
Entrez 882587
GenBank AAG06280.1
INSDC AAG06280.1
NCBI Locus Tag PA2892
protein_id(GenBank) gb|AAG06280.1|AE004715_6|gnl|PseudoCAP|PA2892
TIGR NTL03PA02892
UniParc UPI00000C5867
UniProtKB Acc Q9HZV5
UniProtKB ID Q9HZV5_PSEAE
UniRef100 UniRef100_W0YSR2
UniRef50 UniRef50_V6ACU3
UniRef90 UniRef90_V6ACU3

Product

Feature Type CDS
Coding Frame 1
Product Name
GCase, alpha-subunit (biotin-containing)
Product Name Confidence: Class 3
Synonyms putative short chain dehydrogenase involved in catabolism of citronellol
Evidence for Translation
Charge (pH 7) 0.41
Kyte-Doolittle Hydrophobicity Value -0.016
Molecular Weight (kDa) 29.6
Isoelectric Point (pI) 7.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 650 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002681 (354 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2892
Search term: atuG

Human Homologs

Ensembl 110, assembly GRCh38.p14
hydroxysteroid dehydrogenase like 2 [Source:HGNC Symbol;Acc:HGNC:18572]
E-value: 1.1e-72
Percent Identity: 54.0

References

Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl Environ Microbiol 2006 Jul;72(7):4819-28
PubMed ID: 16820476