Pseudomonas aeruginosa PAO1, PA2903 (cobJ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2903
Name
cobJ
Synonym: cbiH
Replicon chromosome
Genomic location 3256681 - 3258360 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251593.1
GI 15598099
Affymetrix PA2903_cobJ_at
Entrez 882638
GenBank AAG06291.1
INSDC AAG06291.1
NCBI Locus Tag PA2903
protein_id(GenBank) gb|AAG06291.1|AE004716_9|gnl|PseudoCAP|PA2903
TIGR NTL03PA02903
UniParc UPI00000C5872
UniProtKB Acc Q9HZU4
UniProtKB ID Q9HZU4_PSEAE
UniRef100 UniRef100_Q9HZU4
UniRef50 UniRef50_C0RJQ2
UniRef90 UniRef90_Q9HZU4

Product

Feature Type CDS
Coding Frame 1
Product Name
precorrin-3 methylase CobJ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.23
Kyte-Doolittle Hydrophobicity Value 0.125
Molecular Weight (kDa) 58.9
Isoelectric Point (pI) 5.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 338 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002671 (500 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2903
Search term: cobJ

Human Homologs

References

Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.
Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Thibaut D, Debussche L
J Bacteriol 1990 Oct;172(10):5980-90
PubMed ID: 2211521
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F
J Bacteriol 1993 Nov;175(22):7430-40
PubMed ID: 8226690