Pseudomonas aeruginosa PAO1, PA2907 (cobL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2907
Name
cobL
Synonym: cbiE
Synonym: cbiT
Replicon chromosome
Genomic location 3261522 - 3262769 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_251597.1
GI 15598103
Affymetrix PA2907_cobL_at
Entrez 882678
GenBank AAG06295.1
INSDC AAG06295.1
NCBI Locus Tag PA2907
protein_id(GenBank) gb|AAG06295.1|AE004717_1|gnl|PseudoCAP|PA2907
TIGR NTL03PA02907
UniParc UPI00000C5876
UniProtKB Acc Q9HZU0
UniProtKB ID COBL_PSEAE
UniRef100 UniRef100_Q9HZU0
UniRef50 UniRef50_Q9HZU0
UniRef90 UniRef90_Q9HZU0

Product

Feature Type CDS
Coding Frame 1
Product Name
precorrin-6y-dependent methyltransferase CobL
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.70
Kyte-Doolittle Hydrophobicity Value 0.012
Molecular Weight (kDa) 44.1
Isoelectric Point (pI) 8.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 284 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002667 (504 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2907
Search term: cobL

Human Homologs

References

Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.
Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Thibaut D, Debussche L
J Bacteriol 1990 Oct;172(10):5980-90
PubMed ID: 2211521
Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product.
Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J
J Bacteriol 1992 Feb;174(3):1050-2
PubMed ID: 1732195