Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3078
|
Name |
cprS
|
Replicon | chromosome |
Genomic location | 3451506 - 3452801 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_251768.1 |
GI | 15598274 |
Affymetrix | PA3078_at |
Entrez | 882975 |
GenBank | AAG06466.1 |
INSDC | AAG06466.1 |
NCBI Locus Tag | PA3078 |
protein_id(GenBank) | gb|AAG06466.1|AE004731_14|gnl|PseudoCAP|PA3078 |
TIGR | NTL03PA03078 |
UniParc | UPI00000C5905 |
UniProtKB Acc | Q9HZD0 |
UniProtKB ID | Q9HZD0_PSEAE |
UniRef100 | UniRef100_W0YS69 |
UniRef50 | UniRef50_A6V2Z9 |
UniRef90 | UniRef90_A6V2Z9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
CprS
|
Synonyms |
cationic peptide resistance sensor |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -17.60 |
Kyte-Doolittle Hydrophobicity Value | -0.235 |
Molecular Weight (kDa) | 48.4 |
Isoelectric Point (pI) | 4.58 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
cprS | cprS is part of a two-component regulatory system that, with its counterpart cprR, induces the Arn operon in the presence of cationic peptides to confer resistance. [PMID:23006746] | ARO:3005064 | protein homolog model | Perfect | 857.4 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 467 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002514 (325 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3078
Search term: cprS
Search term: CprS
|
A two-component system plays an important role in the root-colonizing ability of Pseudomonas fluorescens strain WCS365.
Dekkers LC, Bloemendaal CJ, de Weger LA, Wijffelman CA, Spaink HP, Lugtenberg BJ
Mol Plant Microbe Interact 1998 Jan;11(1):45-56
PubMed ID: 9425686
|
The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS.
Fernández L, Jenssen H, Bains M, Wiegand I, Gooderham WJ, Hancock RE
Antimicrob Agents Chemother 2012 Dec;56(12):6212-22
PubMed ID: 23006746
|
Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.
Gutu AD, Sgambati N, Strasbourger P, Brannon MK, Jacobs MA, Haugen E, Kaul RK, Johansen HK, Høiby N, Moskowitz SM
Antimicrob Agents Chemother 2013 May;57(5):2204-15
PubMed ID: 23459479
|