Pseudomonas aeruginosa PAO1, PA3104 (xcpP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3104
Name
xcpP
Replicon chromosome
Genomic location 3483642 - 3484349 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251794.1
GI 15598300
Affymetrix PA3104_xcpP_at
DNASU PaCD00007366
Entrez 877805
GenBank AAG06492.1
INSDC AAG06492.1
NCBI Locus Tag PA3104
protein_id(GenBank) gb|AAG06492.1|AE004734_10|gnl|PseudoCAP|PA3104
TIGR NTL03PA03104
UniParc UPI000012BC78
UniProtKB Acc Q51575
UniProtKB ID GSPN_PSEAE
UniRef100 UniRef100_Q51575
UniRef50 UniRef50_Q51575
UniRef90 UniRef90_Q51575

Product

Feature Type CDS
Coding Frame 1
Product Name
secretion protein XcpP
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.04
Kyte-Doolittle Hydrophobicity Value -0.383
Molecular Weight (kDa) 25.5
Isoelectric Point (pI) 5.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002493 (327 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3104
Search term: xcpP

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Xcp-mediated protein secretion in Pseudomonas aeruginosa: identification of two additional genes and evidence for regulation of xcp gene expression.
Akrim M, Bally M, Ball G, Tommassen J, Teerink H, Filloux A, Lazdunski A
Mol Microbiol 1993 Oct;10(2):431-43
PubMed ID: 7934833