Pseudomonas aeruginosa PAO1, PA3152 (hisH2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3152
Name
hisH2
Replicon chromosome
Genomic location 3535971 - 3536579 (- strand)

Cross-References

RefSeq NP_251842.1
GI 15598348
Affymetrix PA3152_hisH2_at
DNASU PaCD00007386
Entrez 882589
GenBank AAG06540.1
INSDC AAG06540.1
NCBI Locus Tag PA3152
protein_id(GenBank) gb|AAG06540.1|AE004739_2|gnl|PseudoCAP|PA3152
TIGR NTL03PA03152
UniParc UPI0000001567
UniProtKB Acc P72138
UniProtKB ID HIS52_PSEAE
UniRef100 UniRef100_P72138
UniRef50 UniRef50_P72138
UniRef90 UniRef90_P72138

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamine amidotransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.14
Kyte-Doolittle Hydrophobicity Value -0.174
Molecular Weight (kDa) 22.7
Isoelectric Point (pI) 7.06

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0085
Category LPS O-antigen (P. aeruginosa)
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG008371 (35 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3152
Search term: hisH2

Human Homologs

References

Imidazole glycerol phosphate synthase: the glutamine amidotransferase in histidine biosynthesis.
Klem TJ, Davisson VJ
Biochemistry 1993 May 18;32(19):5177-86
PubMed ID: 8494895