Pseudomonas aeruginosa PAO1, PA3167 (serC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA3167
Name
serC
Replicon chromosome
Genomic location 3555254 - 3556339 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251857.1
GI 15598363
Affymetrix PA3167_serC_at
DNASU PaCD00007394
Entrez 882700
GenBank AAG06555.1
INSDC AAG06555.1
NCBI Locus Tag PA3167
protein_id(GenBank) gb|AAG06555.1|AE004740_8|gnl|PseudoCAP|PA3167
TIGR NTL03PA03167
UniParc UPI00000C5932
UniProtKB Acc Q9HZ66
UniProtKB ID SERC_PSEAE
UniRef100 UniRef100_Q9HZ66
UniRef50 UniRef50_Q9HZ66
UniRef90 UniRef90_Q9HZ66

Product

Feature Type CDS
Coding Frame 1
Product Name
3-phosphoserine aminotransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -11.09
Kyte-Doolittle Hydrophobicity Value -0.232
Molecular Weight (kDa) 39.9
Isoelectric Point (pI) 4.71

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4XK1 TRANSFERASE 01/09/15 Crystal Structure of a Phosphoserine/phosphohydroxythreonine Aminotransferase (PSAT) from Pseudomonas aeruginosa with cofactor Pyridoxal Phosphate and bound Glutamate PSEUDOMONAS AERUGINOSA (STRAIN ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 2.15 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 323 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002448 (562 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3167
Search term: serC

Human Homologs

Ensembl 86, assembly GRCh38.p7
phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129]
E-value: 1.8e-99
Percent Identity: 50.1

References

Cloning and characterisation of the serC and aroA genes of Yersinia enterocolitica, and construction of an aroA mutant.
O'Gaora P, Maskel D, Coleman D, Cafferkey M, Dougan G
Gene 1989 Dec;84(1):23-30
PubMed ID: 2691337
A probable mixed-function supraoperon in Pseudomonas exhibits gene organization features of both intergenomic conservation and gene shuffling.
Xie G, Bonner CA, Jensen RA
J. Mol. Evol. 1999 Jul;49(1):108-21
PubMed ID: 10368439
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994