Pseudomonas aeruginosa PAO1, PA3337 (rfaD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3337
Name
rfaD
Replicon chromosome
Genomic location 3746078 - 3747076 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252027.1
GI 15598533
Affymetrix PA3337_rfaD_at
Entrez 882502
GenBank AAG06725.1
INSDC AAG06725.1
NCBI Locus Tag PA3337
protein_id(GenBank) gb|AAG06725.1|AE004756_3|gnl|PseudoCAP|PA3337
TIGR NTL03PA03337
UniParc UPI0000453699
UniProtKB Acc Q9HYQ8
UniProtKB ID HLDD_PSEAE
UniRef100 UniRef100_Q9HYQ8
UniRef50 UniRef50_Q9HYQ8
UniRef90 UniRef90_Q9HYQ8

Product

Feature Type CDS
Coding Frame 1
Product Name
ADP-L-glycero-D-mannoheptose 6-epimerase
Product Name Confidence: Class 2
Synonyms ADP-glyceromanno-heptose 6-epimerase.
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.23
Kyte-Doolittle Hydrophobicity Value -0.391
Molecular Weight (kDa) 37.4
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 597 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002291 (342 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3337
Search term: rfaD

Human Homologs

References

A mutation in the Neisseria gonorrhoeae rfaD homolog results in altered lipooligosaccharide expression.
Drazek ES, Stein DC, Deal CD
J Bacteriol 1995 May;177(9):2321-7
PubMed ID: 7730260