Pseudomonas aeruginosa PAO1, PA3476 (rhlI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3476
Name
rhlI
Replicon chromosome
Genomic location 3889139 - 3889744 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252166.1
GI 15598672
Affymetrix PA3476_rhlL_at
DNASU PaCD00007527
Entrez 878967
GenBank AAG06864.1
INSDC AAG06864.1
NCBI Locus Tag PA3476
protein_id(GenBank) gb|AAG06864.1|AE004768_9|gnl|PseudoCAP|PA3476
TIGR NTL03PA03476
UniParc UPI000013387D
UniProtKB Acc P54291
UniProtKB ID RHLI_PSEAE
UniRef100 UniRef100_P54291
UniRef50 UniRef50_P54291
UniRef90 UniRef90_P54291

Product

Feature Type CDS
Coding Frame 1
Product Name
autoinducer synthesis protein RhlI
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -3.41
Kyte-Doolittle Hydrophobicity Value 0.015
Molecular Weight (kDa) 22.6
Isoelectric Point (pI) 5.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0093
Category N-(butanoyl)-L-homoserine lactone QS system
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 61 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002165 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3476
Search term: rhlI

Human Homologs

References

Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1.
Latifi A, Winson MK, Foglino M, Bycroft BW, Stewart GS, Lazdunski A, Williams P
Mol Microbiol 1995 Jul;17(2):333-43
PubMed ID: 7494482