Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3487
|
Name |
tle5
|
Replicon | chromosome |
Genomic location | 3902663 - 3905962 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_252177.1 |
GI | 15598683 |
Affymetrix | PA3487_at |
Entrez | 880040 |
GenBank | AAG06875.1 |
INSDC | AAG06875.1 |
NCBI Locus Tag | PA3487 |
protein_id(GenBank) | gb|AAG06875.1|AE004769_8|gnl|PseudoCAP|PA3487 |
TIGR | NTL03PA03487 |
UniParc | UPI00000C5A35 |
UniProtKB Acc | Q9HYC2 |
UniProtKB ID | Q9HYC2_PSEAE |
UniRef100 | UniRef100_Q9HYC2 |
UniRef50 | UniRef50_Q9HYC2 |
UniRef90 | UniRef90_Q9HYC2 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Tle5
|
Synonyms |
PldA |
Evidence for Translation | |
Charge (pH 7) | -3.85 |
Kyte-Doolittle Hydrophobicity Value | -0.316 |
Molecular Weight (kDa) | 122.3 |
Isoelectric Point (pI) | 6.67 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7V55 | HYDROLASE | 08/16/21 | Crystal structure of phospholipase D from Pseudomonas aeruginosa PAO1 using in situ proteolysis | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 3 | X-RAY DIFFRACTION | 100.0 |
7WDK | IMMUNE SYSTEM | 12/21/21 | The structure of PldA-PA3488 complex | Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 3.05 | ELECTRON MICROSCOPY | 100.0 |
7V53 | HYDROLASE | 08/16/21 | Crystal structure of full-length phospholipase D from Pseudomonas aeruginosa PAO1 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.1 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | VFDB |
Category | Phospholipase D |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Rattus norvegicus |
Notes | |
Infection model | Rat agar bead model of chronic lung infection |
Reference | 11136451 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 26 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002156 (79 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3487
Search term: tle5
Search term: Tle5
|
Ensembl
110, assembly
GRCh38.p14
|
phospholipase D1 [Source:HGNC Symbol;Acc:HGNC:9067]
E-value:
7.9e-26
Percent Identity:
30.7
|
Ensembl
110, assembly
GRCh38.p14
|
phospholipase D1 [Source:HGNC Symbol;Acc:HGNC:9067]
E-value:
7.9e-26
Percent Identity:
30.7
|
Genetic and biochemical analyses of a eukaryotic-like phospholipase D of Pseudomonas aeruginosa suggest horizontal acquisition and a role for persistence in a chronic pulmonary infection model.
Wilderman PJ, Vasil AI, Johnson Z, Vasil ML
Mol Microbiol 2001 Jan;39(2):291-303
PubMed ID: 11136451
|
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
Nature 2013 Apr 25;496(7446):508-12
PubMed ID: 23552891
|
A Pseudomonas aeruginosa type VI secretion phospholipase D effector targets both prokaryotic and eukaryotic cells.
Jiang F, Waterfield NR, Yang J, Yang G, Jin Q
Cell Host Microbe 2014 May 14;15(5):600-10
PubMed ID: 24832454
|
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
|
Biochemical characterization of a Pseudomonas aeruginosa phospholipase D.
Spencer C, Brown HA
Biochemistry 2015 Feb 10;54(5):1208-18
PubMed ID: 25565226
|