Pseudomonas aeruginosa PAO1, PA3522 (mexQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA3522
Name
mexQ
Replicon chromosome
Genomic location 3939492 - 3942653 (- strand)
Transposon Mutants 3 transposon mutants in PAO1

Cross-References

RefSeq NP_252212.1
GI 15598718
Affymetrix PA3522_at
Entrez 878906
GenBank AAG06910.1
INSDC AAG06910.1
NCBI Locus Tag PA3522
protein_id(GenBank) gb|AAG06910.1|AE004772_8|gnl|PseudoCAP|PA3522
TIGR NTL03PA03522
UniParc UPI00000C5A51
UniProtKB Acc Q9HY87
UniProtKB ID Q9HY87_PSEAE
UniRef100 UniRef100_Q9HY87
UniRef50 UniRef50_Q8EBL9
UniRef90 UniRef90_Q9HY87

Product

Feature Type CDS
Coding Frame 1
Product Name
MexQ
Product Name Confidence: Class 3
Evidence for Translation
Charge (pH 7) -9.37
Kyte-Doolittle Hydrophobicity Value 0.469
Molecular Weight (kDa) 112.3
Isoelectric Point (pI) 5.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff E-value Percent Identity CARD Version
adeG AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex. ARO:3000778 protein homolog model Strict 0.0 0.99905 1.1.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 489 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2173 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3522
Search term: mexQ
Search term: MexQ

Transposon Insertions in PAO1

Type mini-Tn5 lux transposon insertion site (Transcriptional fusion)
Mutant ID UBC: PAO1_lux_32_C12
Genomic Position 3940417
Position in ORF 926(3162)
Reference 15805499
Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 36623
Genomic Position 3942264
Position in ORF 2773(3162)
Reference 14617778
Type Confirmed ISlacZ/hah insertion site
Mutant ID UWGC: 7848
Genomic Position 3942413
Position in ORF 2922(3162)
Reference 14617778

Transposon Insertions in Orthologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.
Mima T, Sekiya H, Mizushima T, Kuroda T, Tsuchiya T
Microbiol. Immunol. 2005 ;49(11):999-1002
PubMed ID: 16301811