Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3574
|
Name |
nalD
|
Replicon | chromosome |
Genomic location | 4006510 - 4007148 (+ strand) |
Transposon Mutants | 6 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_252264.1 |
GI | 15598770 |
Affymetrix | PA3574_at |
Entrez | 880183 |
GenBank | AAG06962.1 |
INSDC | AAG06962.1 |
NCBI Locus Tag | PA3574 |
protein_id(GenBank) | gb|AAG06962.1|AE004778_6|gnl|PseudoCAP|PA3574 |
TIGR | NTL03PA03574 |
UniParc | UPI00000C5A74 |
UniProtKB Acc | Q9HY46 |
UniProtKB ID | Q9HY46_PSEAE |
UniRef100 | UniRef100_W0YTN0 |
UniRef50 | UniRef50_B7VAK7 |
UniRef90 | UniRef90_B7VAK7 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
NalD
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -2.70 |
Kyte-Doolittle Hydrophobicity Value | -0.400 |
Molecular Weight (kDa) | 24.5 |
Isoelectric Point (pI) | 6.25 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
nalD | NalD is a repressor of MexAB-OprM. Mutations lead to multidrug resistance and MexAB-OprM overexpression. [PMID:15855496] | ARO:3000819 | protein overexpression model | Strict | 429.5 | 100.0 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
5DAJ | TRANSCRIPTION REGULATOR | 08/20/15 | Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 2.65 | X-RAY DIFFRACTION | 100.0 |
5H9T | TRANSCRIPTION REGULATOR | 12/29/15 | Crystal structure of native NalD at resolution of 2.9, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 2.89 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 330 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002095 (523 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3574
Search term: nalD
Search term: NalD
|
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.
Ma D, Cook DN, Alberti M, Pon NG, Nikaido H, Hearst JE
J Bacteriol 1993 Oct;175(19):6299-313
PubMed ID: 8407802
|
Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa.
Sobel ML, Hocquet D, Cao L, Plesiat P, Poole K
Antimicrob Agents Chemother 2005 May;49(5):1782-6
PubMed ID: 15855496
|