Pseudomonas aeruginosa PAO1, PA3721 (nalC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3721
Name
nalC
Replicon chromosome
Genomic location 4166518 - 4167159 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252410.1
GI 15598916
Affymetrix PA3721_at
DNASU PaCD00007625
Entrez 880362
GenBank AAG07108.1
INSDC AAG07108.1
NCBI Locus Tag PA3721
protein_id(GenBank) gb|AAG07108.1|AE004791_5|gnl|PseudoCAP|PA3721
TIGR NTL03PA03721
UniParc UPI00000C5ADC
UniProtKB Acc Q9HXS0
UniProtKB ID Q9HXS0_PSEAE
UniRef100 UniRef100_Q9HXS0
UniRef50 UniRef50_Q9HXS0
UniRef90 UniRef90_Q9HXS0

Product

Feature Type CDS
Coding Frame 1
Product Name
NalC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -3.89
Kyte-Doolittle Hydrophobicity Value -0.065
Molecular Weight (kDa) 23.5
Isoelectric Point (pI) 5.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
nalC NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. [PMID:27060003, PMID:27412168, PMID:15387820] ARO:3000818 protein overexpression model Strict 418.3 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 298 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001962 (826 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3721
Search term: nalC
Search term: NalC

Human Homologs

References

MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719.
Cao L, Srikumar R, Poole K
Mol Microbiol 2004 Sep;53(5):1423-36
PubMed ID: 15387820