Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3721
|
Name |
nalC
|
Replicon | chromosome |
Genomic location | 4166518 - 4167159 (+ strand) |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_252410.1 |
GI | 15598916 |
Affymetrix | PA3721_at |
DNASU | PaCD00007625 |
Entrez | 880362 |
GenBank | AAG07108.1 |
INSDC | AAG07108.1 |
NCBI Locus Tag | PA3721 |
protein_id(GenBank) | gb|AAG07108.1|AE004791_5|gnl|PseudoCAP|PA3721 |
TIGR | NTL03PA03721 |
UniParc | UPI00000C5ADC |
UniProtKB Acc | Q9HXS0 |
UniProtKB ID | Q9HXS0_PSEAE |
UniRef100 | UniRef100_Q9HXS0 |
UniRef50 | UniRef50_Q9HXS0 |
UniRef90 | UniRef90_Q9HXS0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
NalC
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -3.89 |
Kyte-Doolittle Hydrophobicity Value | -0.065 |
Molecular Weight (kDa) | 23.5 |
Isoelectric Point (pI) | 5.65 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
nalC | NalC is a repressor of PA3720-PA3719, which are positive regulators of MexAB-OprM. Thus, nalC mutants confer multidrug resistance. [PMID:27060003, PMID:27412168, PMID:15387820] | ARO:3000818 | protein overexpression model | Strict | 418.3 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 298 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001962 (826 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3721
Search term: nalC
Search term: NalC
|
MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719.
Cao L, Srikumar R, Poole K
Mol Microbiol 2004 Sep;53(5):1423-36
PubMed ID: 15387820
|