Pseudomonas aeruginosa PAO1, PA3879 (narL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3879
Name
narL
Replicon chromosome
Genomic location 4346875 - 4347534 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252568.1
GI 15599074
Affymetrix PA3879_narL_at
Entrez 878838
GenBank AAG07266.1
INSDC AAG07266.1
NCBI Locus Tag PA3879
protein_id(GenBank) gb|AAG07266.1|AE004805_4|gnl|PseudoCAP|PA3879
TIGR NTL03PA03879
UniParc UPI00000C5B54
UniProtKB Acc Q9HXD3
UniProtKB ID Q9HXD3_PSEAE
UniRef100 UniRef100_W0YYV1
UniRef50 UniRef50_D5VBH7
UniRef90 UniRef90_A6V0M9

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator NarL
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.79
Kyte-Doolittle Hydrophobicity Value -0.200
Molecular Weight (kDa) 24.3
Isoelectric Point (pI) 4.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 617 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001792 (388 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3879
Search term: narL

Human Homologs

References

Mutational analysis of nitrate regulatory gene narL in Escherichia coli K-12.
Egan SM, Stewart V
J Bacteriol 1991 Jul;173(14):4424-32
PubMed ID: 2066339
The OpdQ porin of Pseudomonas aeruginosa is regulated by environmental signals associated with cystic fibrosis including nitrate-induced regulation involving the NarXL two-component system.
Fowler RC, Hanson ND
Microbiologyopen 2015 Dec;4(6):967-82
PubMed ID: 26459101